LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.

doi:10.1016/j.expneurol.2014.05.025

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Article

LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.

Experimental neurology - 1 Nov 2014

Esteves A Raquel, Swerdlow Russell H, Cardoso Sandra M

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a large, ubiquitous protein of unknown function. Mutations in the gene encoding LRRK2 have been linked to familial and sporadic Parkinson's disease (PD) cases. The LRRK2 protein is a single polypeptide that displays GTPase and kinase activity. Kinase and GT...

Topics

Animals
Cytoskeleton
Genetic Predisposition to Disease
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mitochondria
Mutation
Parkinson Disease
Protein Serine-Threonine Kinases
Proteins
alpha-Synuclein

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