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Article

LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.

Experimental neurology - 1 Nov 2014

Esteves A Raquel, Swerdlow Russell H, Cardoso Sandra M

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a large, ubiquitous protein of unknown function. Mutations in the gene encoding LRRK2 have been linked to familial and sporadic Parkinson's disease (PD) cases. The LRRK2 protein is a single polypeptide that displays GTPase and kinase activity. Kinase and GTPase domains are involved in different cellular signaling pathways. Despite several experimental studies associating...

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Identifiers

PMID: 24907399
DOI: 10.1016/j.expneurol.2014.05.025
PMCID: PMC4194231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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