Article
CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration.
Science advances - 22 Nov 2024
Liu Qinfang, Huang Bingxu, Guiberson Noah Guy Lewis, Chen Shifan, Zhu Dong, Ma Gang, Ma Xin-Ming, Crittenden Jill R, Yu Jianzhong, Graybiel Ann M, Dawson Ted M, Dawson Valina L, Xiong Yulan
Abstract excerpt
Mutations in LRRK2 are the most common genetic cause of Parkinson's disease (PD). LRRK2 protein contains two enzymatic domains: a GTPase (Roc-COR) and a kinase domain. Disease-causing mutations are found in both domains. Now, studies have focused largely on LRRK2 kinase activity, while attention to its GTPase function is limited. LRRK2 is a guanine nucleotide-binding protein, but the mechanism of direct...
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