Article
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.
PLoS genetics - 1 Jan 2012
Stafa Klodjan, Trancikova Alzbeta, Webber Philip J, Glauser Liliane, West Andrew B, Moore Darren J
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activity. Initial data indicates that an intact functional GTPase domain is critically required for LRRK2 kinase activity. PD-associated mutations in LRRK2, including the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.