Article
LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.
Biochemical Society transactions - 1 Oct 2012
Xiong Yulan, Dawson Valina L, Dawson Ted M
Abstract excerpt
Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene are the most frequent genetic cause of PD (Parkinson's disease), and these mutations play important roles in sporadic PD. The LRRK2 protein contains GTPase and kinase domains and several protein-protein interaction domains. The kinase and GTPase activity of LRRK2 seem to be important in regulating LRRK2-dependent cellular signalling pathways. LRRK2's...
Topics
- GTP Phosphohydrolases
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- Protein Serine-Threonine Kinases