Article
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
Human molecular genetics - 15 Mar 2013
Biosa Alice, Trancikova Alzbeta, Civiero Laura, Glauser Liliane, Bubacco Luigi, Greggio Elisa, Moore Darren J
Abstract excerpt
Mutations in the LRRK2 gene cause autosomal dominant Parkinson's disease. LRRK2 encodes a multi-domain protein containing a Ras-of-complex (Roc) GTPase domain, a C-terminal of Roc domain and a protein kinase domain. LRRK2 can function as a GTPase and protein kinase, although the interplay between these two enzymatic domains is poorly understood. Although guanine nucleotide binding is critically required for the...
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