Article
BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons.
The Journal of cell biology - 19 Mar 2012
Dieni Sandra, Matsumoto Tomoya, Dekkers Martijn, Rauskolb Stefanie, Ionescu Mihai S, Deogracias Ruben, Gundelfinger Eckart D, Kojima Masami, Nestel Sigrun, Frotscher Michael, Barde Yves-Alain
Abstract excerpt
Although brain-derived neurotrophic factor (BDNF) regulates numerous and complex biological processes including memory retention, its extremely low levels in the mature central nervous system have greatly complicated attempts to reliably localize it. Using rigorous specificity controls, we found that antibodies reacting either with BDNF or its pro-peptide both stained large dense core vesicles in excitatory...
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