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Article

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.

Cell - 25 Mar 1994

Jones K R, Fariñas I, Backus C, Reichardt L F

Abstract excerpt

Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and differentiation of several classes of neurons in vitro. To determine its essential functions, we have mutated the BDNF gene. Most homozygote mutants die within 2 days after birth, but a fraction live for 2-4 weeks. These develop symptoms of nervous system dysfunction, including ataxia. The BDNF mutant homozygotes have...

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Identifiers

PMID: 8137432
DOI: 10.1016/0092-8674(94)90377-8
PMCID: PMC2711896

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.PMID 8137432Read ↗

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