Article
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.
Cell - 25 Mar 1994
Jones K R, Fariñas I, Backus C, Reichardt L F
Abstract excerpt
Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and differentiation of several classes of neurons in vitro. To determine its essential functions, we have mutated the BDNF gene. Most homozygote mutants die within 2 days after birth, but a fraction live for 2-4 weeks...
Topics
- Animals
- Brain
- Brain-Derived Neurotrophic Factor
- Calcium-Binding Proteins
- Cell Division
- Cell Line
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Motor Neurons
- Mutation
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurons, Afferent
- Sequence Deletion