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Article

Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival.

Molecular brain - 13 Aug 2009

Koshimizu Hisatsugu, Kiyosue Kazuyuki, Hara Tomoko, Hazama Shunsuke, Suzuki Shingo, Uegaki Koichi, Nagappan Guhan, Zaitsev Eugene, Hirokawa Takatsugu, Tatsu Yoshiro, Ogura Akihiko, Lu Bai, Kojima Masami

Abstract excerpt

BACKGROUND: Proneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75(NTR)) and Trk tyrosine kinase receptors, respectively; however the molecular roles of proneurotrophins in the CNS are not fully understood. RESULTS: Based on two rare single nucleotide polymorphisms (SNPs) of the human brain-derived neurotrophic factor (BDNF) gene, we generated R125M-, R127L- and...

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Identifiers

PMID: 19674479
DOI: 10.1186/1756-6606-2-27
PMCID: PMC2743674

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival.PMID 19674479Read ↗

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