The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

doi:10.1016/j.neuron.2018.05.024

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Article

The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

Neuron - 11 Jul 2018

Giza Joanna I, Kim Jihye, Meyer Heidi C, Anastasia Agustin, Dincheva Iva, Zheng Crystal I, Lopez Katherine, Bains Henrietta, Yang Jianmin, Bracken Clay, Liston Conor, Jing Deqiang, Hempstead Barbara L, Lee Francis S

Abstract excerpt

A human variant in the BDNF gene (Val66Met; rs6265) is associated with impaired fear extinction. Using super-resolution imaging, we demonstrate that the BDNF Met prodomain disassembles dendritic spines and eliminates synapses in hippocampal neurons. In vivo, ventral CA1 (vCA1) hippocampal neurons undergo similar morphological changes dependent on their transient co-expression of a SorCS2/p75NTR receptor complex...

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PMID: 29909994
DOI: 10.1016/j.neuron.2018.05.024
PMCID: PMC6054457

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BDNF

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