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Article

Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Apr 2004

Baquet Zachary C, Gorski Jessica A, Jones Kevin R

Abstract excerpt

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, modulates neuronal survival, differentiation, and synaptic function. Reduced BDNF expression in the cortex caused by mutation of the huntingtin gene has been suggested to play a role in the striatal degeneration observed in Huntington's disease. BDNF expression rises dramatically in the cortex during the first few weeks of postnatal...

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Identifiers

PMID: 15115821
DOI: 10.1523/JNEUROSCI.3920-03.2004
PMCID: PMC6729276

Genes

BDNF
MSN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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