Article

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons

2025-07-18

Abstract excerpt

Brain derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) play crucial roles in neuronal development, synaptic transmission, and neuroplasticity. Deficits in BDNF/TrkB signalling and trafficking have been identified in several neurodegenerative diseases, including Alzheimer’s disease (AD). Individuals with Down syndrome (DS) are at an increased risk of developing AD compared to...

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Literature Corpus work: 84f93467-1883-5db4-ab65-962cc90a0872
DOI: 10.1101/2025.07.15.664857

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