Article
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.
Cell - 24 Jan 2003
Egan Michael F, Kojima Masami, Callicott Joseph H, Goldberg Terry E, Kolachana Bhaskar S, Bertolino Alessandro, Zaitsev Eugene, Gold Bert, Goldman David, Dean Michael, Lu Bai, Weinberger Daniel R
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine (val) to methionine (met) substitution in the 5' pro-region of the human BDNF protein. In human subjects, the met allele was associated with poorer episodic memory, abnormal hippocampal activation assayed with fMRI, and lower hippocampal...
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