Article
Cell biology of BDNF and its relevance to schizophrenia.
Novartis Foundation symposium - 1 Jan 2008
Lu Bai, Martinowich Keri
Abstract excerpt
BDNF is a key regulator of synaptic plasticity and hence is thought to be uniquely important for various cognitive functions. While correlations of schizophrenia with polymorphisms in the BDNF gene and changes in BDNF mRNA levels have been reported, specific links remain to be established. Cell biology studies may provide clues as to how BDNF signalling impacts schizophrenia aetiology and pathogenesis: (1) the...
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