Article
Functions and mechanisms of BDNF mRNA trafficking.
Novartis Foundation symposium - 1 Jan 2008
Tongiorgi Enrico, Baj Gabriele
Abstract excerpt
Long-lasting changes in the basis of memory storage require delivery of newly synthesized proteins to the affected synapses. While most of these proteins are generated in the cell body, several key molecules for plasticity can be delivered in the form of silent mRNAs at synapses in extra-somatic compartments where they are locally translated in response to specific stimuli. One such mRNA encodes brain derived...
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