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Article

Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Dec 2006

del Toro Daniel, Canals Josep M, Ginés Silvia, Kojima Masami, Egea Gustavo, Alberch Jordi

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) polymorphism is associated with the pathophysiology of several neurodegenerative disorders, including Huntington's disease. In view of these data and the involvement of huntingtin in intracellular trafficking, we examined the intracellular transport and release of Val66Val BDNF (Val-BDNF) and Val66Met BDNF (Met-BDNF) in transfected striatal knock-in cells expressing...

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Identifiers

PMID: 17151278
DOI: 10.1523/JNEUROSCI.3873-06.2006
PMCID: PMC6674849

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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