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Article

GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity.

PloS one - 1 Jan 2012

Lin Jieru Egeria, Snook Adam Eugene, Li Peng, Stoecker Brian Arthur, Kim Gilbert Won, Magee Michael Sullivan, Garcia Alex Vladimir Mejia, Valentino Michael Anthony, Hyslop Terry, Schulz Stephanie, Waldman Scott Arthur

Abstract excerpt

The barrier separating mucosal and systemic compartments comprises epithelial cells, annealed by tight junctions, limiting permeability. GUCY2C recently emerged as an intestinal tumor suppressor coordinating AKT1-dependent crypt-villus homeostasis. Here, the contribution of GUCY2C to barrier integrity opposing colitis and systemic tumorigenesis is defined. Mice deficient in GUCY2C (Gucy2c(-/-)) exhibited barrier...

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Source

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Identifiers

PMID: 22384056
DOI: 10.1371/journal.pone.0031686
PMCID: PMC3284579

Genes

AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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