Article
Therapeutic zinc targets dysregulated GC-C signaling and restores ileal defects in a preclinical model of familial diarrheal disease.
American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2026
Bose Avipsa, Bopanna Yashika, Shetty Pallavi, Sharma Kritica, Mathew John Kandam Kulathu, Mishra Vishwas, Bannerjee Sanghita, Ramani Harini, Pulimood Anna B, Bhat Ramray, Shenoy Avinash R, Visweswariah Sandhya S
Abstract excerpt
Hyperactivating mutations in guanylyl cyclase C (GC-C) are monogenic causes of early-onset inflammatory bowel disease, familial diarrheal syndrome, and congenital secretory diarrhea. The mechanisms linking elevated cGMP levels to immune imbalance remain poorly defined. Here, using a preclinical model of a disease-associated GC-C mutation, we observe pleiotropic alterations in the small intestinal epithelium....
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