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Article

Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.

Cancer research - 15 Jan 2016

Lin Jieru E, Colon-Gonzalez Francheska, Blomain Erik, Kim Gilbert W, Aing Amanda, Stoecker Brian, Rock Justin, Snook Adam E, Zhan Tingting, Hyslop Terry M, Tomczak Michal, Blumberg Richard S, Waldman Scott A

Abstract excerpt

Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universally to malignant progression. In this study, we explored a link between...

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Identifiers

PMID: 26773096
DOI: 10.1158/0008-5472.CAN-15-1467-T
PMCID: PMC4717834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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