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Article

Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.

Gastroenterology - 1 Aug 2007

Li Peng, Schulz Stephanie, Bombonati Alessandro, Palazzo Juan P, Hyslop Terry M, Xu Yihuan, Baran Amy A, Siracusa Linda D, Pitari Giovanni M, Waldman Scott A

Abstract excerpt

BACKGROUND AND AIMS: The most commonly lost gene products in colorectal carcinogenesis include guanylin and uroguanylin, endogenous ligands for guanylyl cyclase C (GCC). Beyond intestinal fluid balance, GCC mediates diarrhea induced by bacterial enterotoxins, and an inverse relationship exists between enterotoxigenic Escherichia coli infections producing the exogenous GCC ligand ST and colorectal cancer...

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Identifiers

PMID: 17681179
DOI: 10.1053/j.gastro.2007.05.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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