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Article

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanisms

8 Feb 2018

Abstract excerpt

Developmental genes contribute to cancer, as reported for the homeobox gene Cdx2 playing a tumor suppressor role in the gut. In this study, we show that human colon cancers exhibiting the highest reduction in CDX2 expression belong to the serrated subtype with the worst evolution. In mice, mosaic knockout of Cdx2 in the adult intestinal epithelium induces the formation of imperfect gastric-type metaplastic...

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Identifiers

PMID: 29439001
DOI: 10.1084/jem.20170934

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