Article

Balance of AKT isoforms in intestinal barrier function. Implications for IBD therapy.

2023-07-04

Abstract excerpt

The leakiness of the intestinal epithelial barrier plays a major role in the development of inflammatory bowel disease. We show that either Akt1 overexpression or Akt2 chemical inhibition have similar effects on intestinal epithelial cells, enhancing the permeability of the barrier and affecting the expression and/or localization of the tight junctions' proteins whereas Akt1 inhibition or Akt2 overexpression show...

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Literature Corpus work: f4ad0f41-add6-562a-8177-19f12f2b1116
DOI: 10.1101/2023.07.04.547629

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