Article
Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.
The Journal of experimental medicine - 1 Nov 2021
Mishra Vishwas, Bose Avipsa, Kiran Shashi, Banerjee Sanghita, Shah Idrees A, Chaukimath Pooja, Reshi Mudasir M, Srinivas Swarna, Barman Anaxee, Visweswariah Sandhya S
Abstract excerpt
Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause early-onset diarrhea and chronic inflammatory bowel disease (IBD). GC-C regulates ion and fluid secretion in the gut via cGMP production and activation of cGMP-dependent protein kinase II. We characterize a novel mouse model harboring an...
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