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Article

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression

13 Mar 2016

Abstract excerpt

Chronic mucosal inflammation is associated with a greater risk of gastric cancer (GC) and, therefore, requires tight control by suppressive counter mechanisms. Gastrokine-2 (GKN2) belongs to a family of secreted proteins expressed within normal gastric mucosal cells. GKN2 expression is frequently lost during GC progression, suggesting an inhibitory role; however, a causal link remains unsubstantiated. Here, we...

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PMID: 26974160
DOI: 10.1172/jci82655

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