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Article

The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.

Gastroenterology - 1 Jan 2010

Lin Jieru Egeria, Li Peng, Snook Adam Eugene, Schulz Stephanie, Dasgupta Abhijit, Hyslop Terry Marie, Gibbons Ahmara Vivian, Marszlowicz Glen, Pitari Giovanni Mario, Waldman Scott Arthur

Abstract excerpt

BACKGROUND & AIMS: GUCY2C is the intestinal receptor for the paracrine hormones guanylin and uroguanylin that converts guanosine-5'-triphosphate to cyclic guanosine monophosphate (cGMP). It functions as a tumor suppressor; its loss disrupts intestinal homeostasis and promotes tumorigenesis. We in...

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Source

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Identifiers

PMID: 19737566
DOI: 10.1053/j.gastro.2009.08.064
PMCID: PMC2813361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19737566-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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