Article

Opposing Roles of Akt isoforms in intestinal epithelial integrity, inflammation and cell renewal: therapeutic implications or Inflammatory Bowel Disease.

2024-03-22

Abstract excerpt

<h4>Background: </h4> Akt1 and Akt2 genetic deficiency in mice have a role in inflammatory bowel disease development, but the mechanism of action is not yet fully understood. <h4>Methods: </h4> Akt (Protein Kinase B) isoform-specific inhibitors were assayed in mouse colon organoids and in a mouse model of colitis induced by dextran sulfate sodium. Mice were monitored in real time for clinical signs including colon...

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Literature Corpus work: bf5ebc1a-d5a3-5efa-97d4-124f32b7e97b
DOI: 10.21203/rs.3.rs-3933502/v1

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