Article
Dissecting the clonal origins of childhood acute lymphoblastic leukemia by single-cell genomics.
Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2014
Gawad Charles, Koh Winston, Quake Stephen R
Abstract excerpt
Many cancers have substantial genomic heterogeneity within a given tumor, and to fully understand that diversity requires the ability to perform single cell analysis. We performed targeted sequencing of a panel of single nucleotide variants (SNVs), deletions, and IgH sequences in 1,479 single tumor cells from six acute lymphoblastic leukemia (ALL) patients. By accurately segregating groups of cooccurring...
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