Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.

The American journal of pathology - 1 Apr 2012

Wolkow Natalie, Song Delu, Song Ying, Chu Sally, Hadziahmetovic Majda, Lee Jennifer C, Iacovelli Jared, Grieco Steven, Dunaief Joshua L

Abstract excerpt

Hephaestin (Heph) is a ferroxidase protein that converts ferrous to ferric iron to facilitate cellular iron export by ferroportin. Many tissues express either Heph or its homologue, ceruloplasmin (Cp), but the retina expresses both. In mice, a combined systemic mutation of Heph and systemic knockout of Cp (Cp(-/-), Heph(sla/sla)) causes retinal iron accumulation and retinal degeneration, with features of human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ceruloplasmin
Share to Iron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macular Degeneration

Share to Membrane Proteins

Share to Mice, Knockout

Share to Photoreceptor Cells, Vertebrate

Share to Proto-Oncogene Proteins pp60(c-src)

Share to Retinal Pigment Epithelium

Source

Open in PubMed Open full text

Identifiers

PMID: 22342521
DOI: 10.1016/j.ajpath.2011.12.041
PMCID: PMC3349827

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.PMID 22342521Read ↗

Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron DisordersSemantic proximity Read ↗

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.Semantic proximity Read ↗

Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response.Semantic proximity Read ↗

Expression and function of iron‐regulatory proteins in retinaSemantic proximity Read ↗

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.Semantic proximity Read ↗

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.Semantic proximity Read ↗

Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer.Semantic proximity Read ↗

Mouse slc9a8 mutants exhibit retinal defects due to retinal pigmented epithelium dysfunction.Semantic proximity Read ↗

Ferrochelatase regulates retinal neovascularizationSemantic proximity Read ↗

CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish.Semantic proximity Read ↗

Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice.Semantic proximity Read ↗

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.