Article

Ferrochelatase regulates retinal neovascularization

2020-06-03

Abstract excerpt

Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo. But FECH has not been explored in retinal neovascularization, which underlies diseases like proliferative diabetic retinopathy and retinopathy of prematurity. Here, we investigated the inhibition of FECH using genetic and chemic...

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Literature Corpus work: d1b3f918-be44-52d3-a327-ca862641973b
DOI: 10.1101/2020.06.02.129650

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