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Article

Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response.

Investigative ophthalmology & visual science - 1 Feb 2021

Sardar Pasha S P B, Shetty Trupti, Lambert-Cheatham Nathan A, Sishtla Kamakshi, Mathew Deepa, Muniyandi Anbukkarasi, Patwari Neeta, Bhatwadekar Ashay D, Corson Timothy W

Abstract excerpt

Purpose: Heme depletion, through inhibition of ferrochelatase (FECH), blocks retinal and choroidal neovascularization. Both pharmacologic FECH inhibition and a partial loss-of-function Fech mutation (Fechm1Pas) are associated with decreased neovascularization. However, the ocular physiology of Fechm1Pas mice under basal conditions has not been characterized. Here, we aimed to characterize the retinal phenotype of...

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Identifiers

PMID: 33620374
DOI: 10.1167/iovs.62.2.36
PMCID: PMC7910629

Genes

FECH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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