Article
Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.
Scientific reports - 19 Dec 2016
Jiang Bo, Liu Guohao, Zheng Jiashuo, Chen Mengxia, Maimaitiming Zaitunamu, Chen Min, Liu Shunli, Jiang Ruiwei, Fuqua Brie K, Dunaief Joshua L, Vulpe Chris D, Anderson Gregory J, Wang Hongwei, Chen Huijun
Abstract excerpt
Multicopper ferroxidases (MCFs) play an important role in cellular iron homeostasis. However, the role of MCFs in renal metabolism remains unclear. We used Hephaestin (Heph) and Ceruloplasmin (Cp) single or double (Heph/Cp) knockout (KO) mice to study the roles of MCFs in the kidney. Renal iron levels and the expression of iron metabolism genes were examined. The non-heme iron content both in the renal cortex and...
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