Article
Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.
Journal of neurochemistry - 1 Dec 2015
Zhao Liangliang, Hadziahmetovic Majda, Wang Chenguang, Xu Xueying, Song Ying, Jinnah H A, Wodzinska Jolanta, Iacovelli Jared, Wolkow Natalie, Krajacic Predrag, Weissberger Alyssa Cwanger, Connelly John, Spino Michael, Lee Michael K, Connor James, Giasson Benoit, Harris Z Leah, Dunaief Joshua L
Abstract excerpt
Brain iron accumulates in several neurodegenerative diseases and can cause oxidative damage, but mechanisms of brain iron homeostasis are incompletely understood. Patients with mutations in the cellular iron-exporting ferroxidase ceruloplasmin (Cp) have brain iron accumulation causing neurodegeneration. Here, we assessed the brains of mice with combined mutation of Cp and its homolog hephaestin. Compared to...
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