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Article

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.

Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 1999

Harris Z L, Durley A P, Man T K, Gitlin J D

Abstract excerpt

Aceruloplasminemia is an autosomal recessive disorder of iron metabolism. Affected individuals evidence iron accumulation in tissue parenchyma in association with absent serum ceruloplasmin. Genetic studies of such patients reveal inherited mutations in the ceruloplasmin gene. To elucidate the role of ceruloplasmin in iron homeostasis, we created an animal model of aceruloplasminemia by disrupting the murine...

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Identifiers

PMID: 10485908
DOI: 10.1073/pnas.96.19.10812
PMCID: PMC17965

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