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Article

Mouse slc9a8 mutants exhibit retinal defects due to retinal pigmented epithelium dysfunction.

Investigative ophthalmology & visual science - 1 May 2015

Jadeja Shalini, Barnard Alun R, McKie Lisa, Cross Sally H, White Jacqueline K, Robertson Morag, Budd Peter S, MacLaren Robert E, Jackson Ian J

Abstract excerpt

PURPOSE: As part of a large scale systematic screen to determine the effects of gene knockout mutations in mice, a retinal phenotype was found in mice lacking the Slc9a8 gene, encoding the sodium/hydrogen ion exchange protein NHE8. We aimed to characterize the mutant phenotype and the role of sodium/hydrogen ion exchange in retinal function. METHODS: Detailed histology characterized the pathological consequences...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25736793
DOI: 10.1167/iovs.14-15735
PMCID: PMC4538965

Genes

RPE
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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