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Article

Expression and function of iron‐regulatory proteins in retina

31 Mar 2010

Abstract excerpt

Iron is essential for cell survival and function; yet excess iron is toxic to cells. Therefore, the cellular and whole-body levels of iron are regulated exquisitely. At least a dozen proteins participate in the regulation of iron homeostasis. Hemochromatosis, a genetic disorder of iron overload, is caused by mutations in at least five genes, namely HFE, hemojuvelin, Transferrin receptor 2, ferroportin, and...

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PMID: 20408179
DOI: 10.1002/iub.326

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