Article
CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish.
Human molecular genetics - 15 Jun 2017
Yu Shanshan, Li Chang, Biswas Lincoln, Hu Xuebin, Liu Fei, Reilly James, Liu Xiliang, Liu Ying, Huang Yuwen, Lu Zhaojing, Han Shanshan, Wang Lei, Yu Liu Jing, Jiang Tao, Shu Xinhua, Wong Fulton, Tang Zhaohui, Liu Mugen
Abstract excerpt
In humans, CERKL mutations cause widespread retinal degeneration: early dysfunction and loss of rod and cone photoreceptors in the outer retina and, progressively, death of cells in the inner retina. Despite intensive efforts, the function of CERKL remains obscure and studies in animal models have failed to clarify the disease mechanism of CERKL mutations. To address this gap in knowledge, we have generated a...
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