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Article

Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer.

Biochimica et biophysica acta - 1 Aug 2012

Garanto Alejandro, Vicente-Tejedor Javier, Riera Marina, de la Villa Pedro, Gonzàlez-Duarte Roser, Blanco Román, Marfany Gemma

Abstract excerpt

In order to approach the function of the retinal dystrophy CERKL gene we generated a novel knockout mouse model by cre-mediated targeted deletion of the Cerkl first exon and proximal promoter. The excised genomic region (2.3kb) encompassed the first Cerkl exon, upstream sequences including the proximal promoter and the initial segment of the first intron. The Cerkl-/- mice were viable and fertile. The targeted...

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Source

Identifiers

PMID: 22549043
DOI: 10.1016/j.bbadis.2012.04.004

Genes

CERKL
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer.PMID 22549043Read ↗

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