Article
Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2018
Fuqua Brie K, Lu Yan, Frazer David M, Darshan Deepak, Wilkins Sarah J, Dunn Linda, Loguinov Alex V, Kogan Scott C, Matak Pavle, Chen Huijun, Dunaief Joshua L, Vulpe Chris D, Anderson Gregory J
Abstract excerpt
Background & Aims: Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe2+ from the iron exporter ferroportin 1 for delivery to the circulating Fe3+ carrier transferrin. Hephaestin (HEPH), the only MCF known to be expressed in enterocytes, aids in the basolateral transfer of dietary iron to the blood. Mice lacking...
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