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Article

Hypermutation of ApoB mRNA by rat APOBEC-1 overexpression mimics APOBEC-3 hypermutation.

Journal of molecular biology - 20 Apr 2012

Chen Zhigang, Eggerman Thomas L, Bocharov Alexander V, Baranova Irina N, Vishnyakova Tatyana G, Kurlander Roger J, Csako Gyorgy, Patterson Amy P

Abstract excerpt

APOBEC-3 proteins induce C-to-U hypermutations in the viral genome of various viruses and have broad antiviral activity. Generally, only a small proportion of viral genomes (<10(-)(2)) are hypermutated by APOBEC-3s, but often many cytidines (up to 40%) are converted into uridine. The mechanism of...

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Identifiers

PMID: 22326345
DOI: 10.1016/j.jmb.2012.02.005
PMCID: PMC3311742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22326345-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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