Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermutation induced by APOBEC-1 overexpression can be eliminated.

RNA (New York, N.Y.) - 1 May 2010

Chen Zhigang, Eggerman Thomas L, Bocharov Alexander V, Baranova Irina N, Vishnyakova Tatyana G, Csako Gyorgy, Patterson Amy P

Abstract excerpt

APOBEC-1 overexpression in liver has been shown to effectively reduce apoB-100 levels. However, nonspecific hypermutation and liver tumor formation potentially related to hypermutation in transgenic animals compromise its potential use for gene therapy. In studying apoB mRNA editing regulation, we found that the core editing auxiliary factor ACF dose-dependently increases APOBEC-1 nonspecific hypermutation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC-1 Deaminase
Share to Apolipoproteins B

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

Share to Cytidine Deaminase

Share to Hepatocytes

Share to Isoenzymes

Share to RNA-Binding Proteins

Share to RNA Editing

Source

Open in PubMed Open full text

Identifiers

PMID: 20348446
DOI: 10.1261/rna.1863010
PMCID: PMC2856876

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermutation induced by APOBEC-1 overexpression can be eliminated.PMID 20348446Read ↗

Hypermutation of ApoB mRNA by rat APOBEC-1 overexpression mimics APOBEC-3 hypermutation.Semantic proximity Read ↗

Low Expression of the Apolipoprotein B mRNA–Editing Transgene in Mice Reduces LDL Levels but Does Not Cause Liver Dysplasia or TumorsSemantic proximity Read ↗

Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.Semantic proximity Read ↗

Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality.Semantic proximity Read ↗

Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing.Semantic proximity Read ↗

Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.Semantic proximity Read ↗

Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice.Semantic proximity Read ↗

Exon 10 skipping in ACAT1 caused by a novel c.949G>A mutation located at an exonic splice enhancer site.Semantic proximity Read ↗

Extinction of alpha 1-antitrypsin gene expression in somatic cell hybrids: evidence for multiple controls.Semantic proximity Read ↗

RNA editing of apolipoprotein B mRNA. Sequence specificity determined by in vitro coupled transcription editing.Semantic proximity Read ↗

Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.Semantic proximity Read ↗

Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3' efficiency element.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.