Article
Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes.
Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2004
Machida Keigo, Cheng Kevin T-N, Sung Vicky M-H, Shimodaira Shigetaka, Lindsay Karen L, Levine Alexandra M, Lai Ming-Yang, Lai Michael M C
Abstract excerpt
Hepatitis C virus (HCV) is a nonretroviral oncogenic RNA virus, which is frequently associated with hepatocellular carcinoma (HCC) and B cell lymphoma. We demonstrated here that acute and chronic HCV infection caused a 5- to 10-fold increase in mutation frequency in Ig heavy chain, BCL-6, p53, and beta-catenin genes of in vitro HCV-infected B cell lines and HCV-associated peripheral blood mononuclear cells,...
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