Article
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.
Hepatology (Baltimore, Md.) - 1 Dec 2007
Xu Rongzhen, Zhang Xuzhao, Zhang Wei, Fang Yongmin, Zheng Shu, Yu Xiao-Fang
Abstract excerpt
UNLABELLED: Human APOBEC3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3) cytidine deaminases have been shown to be potent inhibitors of diverse retroviruses including Vif-deficient human immunodeficiency virus 1 (HIV-1), hepatitis virus B (HBV), adeno-associated virus, and endogenous retroelements. Despite the fact that these enzymes are known to be potential DNA mutators and to target retroviral...
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