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Article

APOBEC3-induced mutation of the hepatitis virus B DNA genome occurs during its viral RNA reverse transcription into (-)-DNA.

The Journal of biological chemistry - 1 Aug 2021

Chen Zhigang, Eggerman Thomas L, Bocharov Alexander V, Baranova Irina N, Vishnyakova Tatyana G, Patterson Amy P

Abstract excerpt

APOBEC3s are innate single-stranded DNA cytidine-to-uridine deaminases that catalyze mutations in both pathogen and human genomes with significant roles in human disease. However, how APOBEC3s mutate a single-stranded DNA that is available momentarily during DNA transcription or replication in vivo remains relatively unknown. In this study, utilizing hepatitis B virus (HBV) viral mutations, we evaluated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34181944
DOI: 10.1016/j.jbc.2021.100889
PMCID: PMC8321922

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