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Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H

17 Apr 2008

Abstract excerpt

Hepatitis B virus (HBV) is a DNA virus that causes liver disease and replicates by reverse transcription of an RNA template. Previous studies have reported that HBV genomes bearing G-->A hypermutation are present at low frequency in human serum. These mutations are most likely due to the activity of apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like (APOBEC) cytosine deaminases, cellular proteins...

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PMID: 18420796
DOI: 10.1099/vir.0.83507-0

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