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Article

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

Blood - 23 Feb 2012

Ma Peisong, Cierniewska Aleksandra, Signarvic Rachel, Cieslak Marcin, Kong Hong, Sinnamon Andrew J, Neubig Richard R, Newman Debra K, Stalker Timothy J, Brass Lawrence F

Abstract excerpt

Platelets are essential for normal hemostasis, but close regulation is required to avoid the destructive effects of either inappropriate platelet activation or excessive responses to injury. Here, we describe a novel complex comprising the scaffold protein, spinophilin (SPL), and the tyrosine phosphatase, SHP-1, and show that it can modulate platelet activation by sequestering RGS10 and RGS18, 2 members of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22210881
DOI: 10.1182/blood-2011-10-387910
PMCID: PMC3293648

Genes

RGS10
RGS18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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