Article
Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.
The Journal of biological chemistry - 18 Oct 2002
Yamao Takuji, Noguchi Tetsuya, Takeuchi Osamu, Nishiyama Uichi, Morita Haruhiko, Hagiwara Tetsuya, Akahori Hironori, Kato Takashi, Inagaki Kenjiro, Okazawa Hideki, Hayashi Yoshitake, Matozaki Takashi, Takeda Kiyoshi, Akira Shizuo, Kasuga Masato
Abstract excerpt
SHPS-1 is a receptor-type glycoprotein that binds and activates the protein-tyrosine phosphatases SHP-1 and SHP-2, and thereby negatively modulates intracellular signaling initiated by various cell surface receptors coupled to tyrosine kinases. SHPS-1 also regulates intercellular communication in the neural and immune systems through its association with CD47 (integrin-associated protein) on adjacent cells....
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