A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

doi:10.1084/jem.20100222

Article

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

16 Aug 2010

Abstract excerpt

Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX-V to the underlying cytoskeleton in platelets. Because FlnA deficiency is embryonic lethal, mice lacking FlnA in platelets were generated by breeding FlnA(loxP/loxP) females with GATA1-Cre males. FlnA(loxP/y) GATA1-Cre males have a macrothrombocytopenia and increased tail bleeding times. FlnA-null platelets have...

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