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Defining and Harnessing the Megakaryocyte/Platelet Checkpoint

24 Feb 2025

Abstract excerpt

Platelets, or thrombocytes are anucleate cell fragments of megakaryocytes (MKs) that are highly reactive to sites of vascular injury and implicated in many pathologies. However, the molecular mechanisms regulating the number and activity of platelets in the circulation remain undefined. The primary outstanding question remains what is the triggering mechanism of platelet production, or thrombopoiesis? Putative...

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PMID: 39991916
DOI: 10.1080/10985549.2025.2451279

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