Article
RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury.
Blood - 23 Dec 2010
Signarvic Rachel S, Cierniewska Aleksandra, Stalker Timothy J, Fong Karen P, Chatterjee Manash S, Hess Paul R, Ma Peisong, Diamond Scott L, Neubig Richard R, Brass Lawrence F
Abstract excerpt
Although much is known about extrinsic regulators of platelet function such as nitric oxide and prostaglandin I(2) (PGI(2)), considerably less is known about intrinsic mechanisms that prevent overly robust platelet activation after vascular injury. Here we provide the first evidence that regulators of G-protein signaling (RGS) proteins serve this role in platelets, using mice with a G184S substitution in G(i2α)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.