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Article

Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2017

Liu Yangyang, Hu Mengjiao, Luo Dongjiao, Yue Ming, Wang Shuai, Chen Xiaoyan, Zhou Yangfan, Wang Yi, Cai Yanchun, Hu Xiaolan, Ke Yuehai, Yang Zhongzhou, Hu Hu

Abstract excerpt

OBJECTIVE: Class III phosphoinositide 3-kinase, also known as VPS34 (vacuolar protein sorting 34), is a highly conserved enzyme regulating important cellular functions such as NADPH oxidase (NOX) assembly, membrane trafficking, and autophagy. Although VPS34 is expressed in platelets, its involvement in platelet activation remains unclear. Herein, we investigated the role of VPS34 in platelet activation and...

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Identifiers

PMID: 28882875
DOI: 10.1161/ATVBAHA.117.309751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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