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Article

Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth.

The Journal of clinical investigation - 1 Apr 2007

Séverin Sonia, Gratacap Marie-Pierre, Lenain Nadège, Alvarez Laetitia, Hollande Etienne, Penninger Josef M, Gachet Christian, Plantavid Monique, Payrastre Bernard

Abstract excerpt

Platelets are critical for normal hemostasis. Their deregulation can lead to bleeding or to arterial thrombosis, a primary cause of heart attack and ischemic stroke. Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a 5-phosphatase capable of dephosphorylating the phosphatidylinositol 3,4,5-trisphosphate second messenger into phosphatidylinositol 3,4-bisphosphate. SHIP1 plays a critical role in...

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Identifiers

PMID: 17347685
DOI: 10.1172/JCI29967
PMCID: PMC1810573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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